A case study of brain morphometry in triplets discordant for Down syndrome. (28th March 2015)

• Record Type: Journal Article
• Authors: Adeyemi, Elizabeth I.; Giedd, Jay N.; Lee, Nancy Raitano
• Is Part Of: American journal of medical genetics. Volume 167:Number 5(2015:May)
• Page Start: 1107
• Page End: 1110
• Publication Date: 2015-03-28
• Subjects: Medical genetics -- Periodicals; 616.14205
• DOI: 10.1002/ajmg.a.36820
• Languages: English
• ISSNs: 1552-4825

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ajmga36820-sec-0001" sec-type="section"> <p>Down syndrome, the most common genetic cause of intellectual disability, offers the opportunity to explore the associations between genetics and both neuroanatomic and neuropsychological phenotypes. This case report summarizes the findings of a neuroimaging and neuropsychology study of two adolescent females with Down syndrome and their same‐sex discordant triplet siblings (one from each family; n = 4). Using high‐resolution magnetic resonance imaging and surface based morphometric approaches, we offer the first in vivo report of cortical surface area reductions and increases in the thickness of the cortical sheet in youth with Down syndrome relative to their typically developing same‐sex triplet siblings. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>