Hearing preservation using topical dexamethasone alone and associated with hyaluronic acid in cochlear implantation. (May 2015)

• Record Type: Journal Article
• Authors: Ramos, Bernardo Faria; Tsuji, Robinson Koji; Bento, Ricardo Ferreira; Goffi-Gomez, Maria Valeria Schmidt; Ramos, Henrique Faria; Samuel, Paola Angelica; Brito, Rubens
• Is Part Of: Acta oto-laryngologica. Volume 135:Number 5(2015)
• Page Start: 473
• Page End: 477
• Publication Date: 2015-05
• Subjects: Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.3109/00016489.2014.995831
• Languages: English
• ISSNs: 0001-6489

Abstract

<abstract> <title>Abstract</title> <p> <italic>Conclusion:</italic> Topical dexamethasone associated with hyaluronic acid in cochlear implant surgery demonstrated a statistically significant difference in the preservation of low-frequency thresholds when compared with topical dexamethasone alone and a control group. Topical dexamethasone alone was not superior in hearing preservation when compared to the control group. <italic>Objective:</italic> To compare the effects of topical dexamethasone alone and associated with hyaluronic acid intraoperatively in hearing preservation in cochlear implantation. <italic>Methods:</italic> Eighteen severely to profoundly hearing-impaired adult patients with measurable hearing were divided into three groups preoperatively: cochlear implantation as a control group (group 1), cochlear implantation using topical dexamethasone intraoperatively (group 2), and cochlear implantation using topical dexamethasone associated with hyaluronic acid intraoperatively (group 3). Preimplant and postimplant low-frequency pure-tone averages (PTAs) were calculated from unaided audiograms at 125, 250, and 500 Hz. <italic>Results:</italic> The mean changes in the low-frequency PTA comparing postoperative against preoperative thresholds were 28.03 ± 6.77 dB in group 1, 30 ± 14.53 dB in group 2, and 7.23 ± 6.12 dB in group 3. There was statistical difference when comparing group 3 with groups 1 and 2 using one-way ANOVA (<italic>p</italic> = 0.002) followed by Scheffé <italic>post hoc</italic> test.</p> </abstract>