Accelerated epigenetic aging in Down syndrome. Issue 3 (9th February 2015)

• Record Type: Journal Article
• Authors: Horvath, Steve; Garagnani, Paolo; Bacalini, Maria Giulia; Pirazzini, Chiara; Salvioli, Stefano; Gentilini, Davide; Di Blasio, Anna Maria; Giuliani, Cristina; Tung, Spencer; Vinters, Harry V.; Franceschi, Claudio
• Is Part Of: Aging cell. Volume 14:Issue 3(2015:Jun.)
• Page Start: 491
• Page End: 495
• Publication Date: 2015-02-09
• Subjects: Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.12325
• Languages: English
• ISSNs: 1474-9718

Abstract

<abstract abstract-type="main" id="acel12325-abs-0001"> <title>Summary</title> <p>Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, <italic>P </italic>= 7.0 × 10⁻¹⁴).</p> </abstract>