Association of TGF‐β1 −509C/T, +869T/C, and +915G/C polymorphisms with periodontitis susceptibility. (19th December 2014)

• Record Type: Journal Article
• Authors: Huang, J; Ding, C; Chen, X; He, R; Chen, N
• Is Part Of: Oral diseases. Volume 21:Number 4(2015:May)
• Page Start: 443
• Page End: 450
• Publication Date: 2014-12-19
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12297
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12297-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12297-sec-0001" sec-type="section"> <title>Objectives</title> <p>To investigate the potential association of <italic>TGF‐β1</italic> −509C/T (rs1800469), +869T/C (rs1800470), and +915G/C (rs1800471) polymorphisms with susceptibility to periodontitis.</p> </sec> <sec id="odi12297-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Several electronic databases were searched for eligible articles. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were calculated to assess the strength of relationship between the <italic>TGF‐β1</italic> polymorphisms and periodontitis risk.</p> </sec> <sec id="odi12297-sec-0003" sec-type="section"> <title>Results</title> <p>Eleven studies were searched without any language restriction. Pooled estimates showed that <italic>TGF‐β1</italic> −509C/T polymorphism was associated with decreased risk of periodontitis. Subgroup analysis revealed that −509C/T T allele was associated with decreased risk of chronic periodontitis (CP) in Asians (T allele <italic>vs </italic>C allele: OR = 0.81, 95% CI = 0.69–0.97, <italic>P</italic><sub>heterogeneity</sub> = 0.25). Furthermore, the +915G/C CC genotype might be associated with elevated risk of CP in Caucasians (CC <italic>vs </italic>GG: OR = 9.14, 95% CI = 1.01–82.50, <italic>P</italic><sub>heterogeneity</sub> = 0.49). Concerning +869T/C polymorphism, no evidence of significant association was identified.</p> </sec> <sec id="odi12297-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This meta‐analysis suggested that <italic>TGF‐β1</italic> −509C/T T allele was associated with decreased risk of CP in Asians, while +915G/C CC genotype might contribute to increased CP risk in Caucasians. Replication studies of our results in independent large populations are necessary to validate this association in diverse populations.</p> </sec> </abstract>