A case of cord capillary hemangioma of the spleen: A recently proven true neoplasm. (2nd March 2015)

• Record Type: Journal Article
• Authors: Tajima, Shogo; Koda, Kenji
• Is Part Of: Pathology international. Volume 65:Number 5(2015:May)
• Page Start: 254
• Page End: 258
• Publication Date: 2015-03-02
• Subjects: Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12277
• Languages: English
• ISSNs: 1320-5463

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Cord capillary hemangioma (CCH) of the spleen is an extremely rare lesion. Once classified under splenic hamartoma, CCH is now differentiated from hamartoma, as its clonality has recently been proven. Herein, we present the case of an incidentally found CCH, measuring 6 × 5.5 × 5 cm, in a 45‐year‐old man. He underwent splenectomy and has been recurrence‐free for 8 years. Macroscopically, the cut surface of the mass showed a central stellate scar with peripheral interspersed reddish areas of variable sizes and intervening fibrous bands. Microscopically, the mass was well demarcated from the splenic tissue. The macroscopic reddish areas were found to correspond to nodules of various sizes, which were predominantly composed of CD34‐expressing capillaries without the presence of CD8‐expressing sinuses. The relative proportion of these two types of vessels distinguishes CCH from sclerosing angiomatoid nodular transformation (SANT), as SANT shows the apparent presence of CD8‐expressing sinuses. In longstanding cases of SANT, sinuses might become ambiguous and the differences between CCH and SANT might become subtle. Nonetheless, immunohistochemistry should be performed when these conditions are suspected, since accurate distinction is usually achieved as a result.</p> </abstract>