Microwave‐assisted radiosynthesis of [18F]ASEM, a radiolabeled α7‐nicotinic acetylcholine receptor antagonist1. (26th February 2015)

• Record Type: Journal Article
• Authors: Ravert, Hayden T.; Holt, Daniel P.; Gao, Yongjun; Horti, Andrew G.; Dannals, Robert F.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 58:Number 4(2015)
• Page Start: 180
• Page End: 182
• Publication Date: 2015-02-26
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3275
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>An improvement of the original radiochemical synthesis of [¹⁸F]ASEM, an <italic>α</italic>7‐nicotinic acetylcholinergic receptor radioligand, is reported. The new procedure utilizes microwave‐assisted radiofluorination. In addition, a new preparative HPLC method was developed to eliminate a chemical impurity in the final product. Quality control procedures were also enhanced to improve detection of product with enhanced resolution of potential impurities. [¹⁸F]ASEM was produced in 20.1 ± 8.9% non‐decay corrected (NDC) yield with an average synthesis time of 57 min and an average specific radioactivity of 856 ± 332 GBq/µmol (23 ± 9 Ci/µmol).</p> </abstract>