Regioselective Acceptorless Dehydrogenative Coupling of N‐Heterocycles toward Functionalized Quinolines, Phenanthrolines, and Indoles1. Issue 17 (10th March 2015)

• Record Type: Journal Article
• Authors: Talwar, Dinesh; Gonzalez‐de‐Castro, Angela; Li, Ho Yin; Xiao, Jianliang
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 17(2015)
• Page Start: 5223
• Page End: 5227
• Publication Date: 2015-03-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201500346
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new strategy has been developed for the oxidant‐ and base‐free dehydrogenative coupling of N‐heterocycles at mild conditions. Under the action of an iridium catalyst, N‐heterocycles undergo multiple sp³ CH activation steps, generating a nucleophilic enamine that reacts in situ with various electrophiles to give highly functionalized products. The dehydrogenative coupling can be cascaded with Friedel–Crafts addition, resulting in a double functionalization of the N‐heterocycles.</p> </abstract>