Boron–18F containing positron emission tomography radiotracers: advances and opportunities. (8th August 2014)

• Record Type: Journal Article
• Authors: Burke, Benjamin P.; Clemente, Gonçalo S.; Archibald, Stephen J.
• Is Part Of: Contrast media & molecular imaging. Volume 10:Number 2(2015:Mar./Apr.)
• Page Start: 96
• Page End: 110
• Publication Date: 2014-08-08
• Subjects: Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1002/cmmi.1615
• Languages: English
• ISSNs: 1555-4309

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Standard [¹⁸F]fluorination methods to form carbon–fluorine bonds can have some limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the formation of boron–[¹⁸F]fluorine bonds and have the potential to give high specific activities at room temperature forming a bond that is stable <italic>in vivo</italic>. There is considerable potential in future applications, particularly in relation to multimodal imaging and the provision of rapid efficient labelling protocols. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>