Association of Monocyte Chemoattractant Protein‐1 (MCP‐1)‐2518A>G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta‐Analysis. (27th February 2015)

• Record Type: Journal Article
• Authors: Bai, Xiao‐Yan; Li, Shujing; Wang, Miao; Qu, Xinjian; Hu, Gaolei; Xu, Zhaowei; Chen, Min; He, Guo‐Wei; Wu, Huijian
• Is Part Of: Annals of human genetics. Volume 79:Number 3(2015:May)
• Page Start: 173
• Page End: 187
• Publication Date: 2015-02-27
• Subjects: Human genetics -- Periodicals; 599.935
• DOI: 10.1111/ahg.12105
• Languages: English
• ISSNs: 0003-4800

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p>We attempted to systematically elucidate the association between monocyte chemoattractant protein‐1 (<italic>MCP‐1</italic>) ‐2518A>G polymorphism and risk of coronary artery disease (CAD). Eligible studies were identified through PubMed, EBSCO, and Web of Science Databases. The magnitude of <italic>MCP‐1</italic> polymorphism effect and its possible mode of action on CAD were estimated. The odds ratio (OR) with 95% confidence intervals (CI) were pooled in a specific genetic model to assess the association. A total of 21 studies were involved. There was significant gene effect on CAD risk in the overall population (likelihood ratio test: <italic>p</italic> < 0.0001). Patients with GG and AG genotypes had 1.435 (95% CI: 1.183–1.740) and 1.087 (95% CI: 1.008–1.172) times higher risk of CAD than those with AA genotype. These gene effects suggested a recessive model to be appropriate. The pooled OR was 1.362 (95% CI: 1.137–1.631; <italic>p</italic><sub>uncorrected</sub> = 0.001, <italic>p</italic><sub>FDR</sub> = 0.005) in the recessive model. In the ethnicity‐stratified analysis, significant association was observed in the Caucasian population (OR = 1.492; 95% CI: 1.106–2.014; <italic>p</italic><sub>uncorrected</sub> = 0.009, <italic>p</italic><sub>FDR</sub> = 0.015), whereas no statistical significant association was detected in the Asian population (adjusted <italic>p</italic> = 0.124). The results suggested that <italic>MCP‐1</italic> ‐2518A>G polymorphism may be associated with susceptibility to CAD, especially in Caucasians.</p> </abstract>