Detection of tumor ALK status in neuroblastoma patients using peripheral blood. (4th February 2015)

• Record Type: Journal Article
• Authors: Combaret, Valérie; Iacono, Isabelle; Bellini, Angela; Bréjon, Stéphanie; Bernard, Virginie; Marabelle, Aurélien; Coze, Carole; Pierron, Gaelle; Lapouble, Eve; Schleiermacher, Gudrun; Blay, Jean Yves
• Is Part Of: Cancer medicine. Volume 4:Number 4(2015:Apr.)
• Page Start: 540
• Page End: 550
• Publication Date: 2015-02-04
• Subjects: 616.994005
• DOI: 10.1002/cam4.414
• Languages: English
• ISSNs: 2045-7634

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="cam4414-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In the present report, by targeting the F1174 and R1275 hotspots of <italic>ALK</italic> gene and using the droplet digital PCR system, we demonstrate that <italic>ALK</italic> mutations are detectable in cell‐free plasma DNA from neuroblastoma patients showing a high risk of relapse. This assay offers a reliable, noninvasive blood test to assess <italic>ALK</italic> mutational status at F1174 and R1275 hotspots and should help the clinicians to identify patients showing an <italic>ALK</italic> mutation in particular when no tumor tissue is available. <boxed-text content-type="graphic" id="cam4414-blkfxd-0001" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjj256km5" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>