Association between CARD8 rs2043211 Polymorphism and Inflammatory Bowel Disease: A Meta-Analysis. (April 2015)

• Record Type: Journal Article
• Authors: Liu, Juan; Liu, Yan-Yan; Liu, Jie; Li, Bao-Zhu; Cen, Han; Xu, Wang-Dong; Leng, Rui-Xue; Pan, Hai-Feng; Ye, Dong-Qing
• Is Part Of: Immunological investigations. Volume 44:Number 3(2015)
• Page Start: 253
• Page End: 264
• Publication Date: 2015-04
• Subjects: Immunology -- Periodicals; Immunochemistry -- Periodicals; Cellular immunity -- Periodicals; Communicable diseases -- Periodicals; 616.079
• DOI: 10.3109/08820139.2014.988721
• Languages: English
• ISSNs: 0882-0139

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>: The aim of this study was to determine whether caspase recruitment domain-containing protein 8 (CARD8) rs2043211 polymorphism was associated with susceptibility to inflammatory bowel disease (IBD).</p> <p> <italic>Methods</italic>: Relevant studies were searched using PubMed and Embase up to February 2014. A meta-analysis was conducted on the association between rs2043211 polymorphism and IBD using: (1) allele contrast, (2) the dominant model, (3) the recessive model, and (4) homozygote contrast. The pooled estimated of risk was obtained by random-effects model or fixed-effects model. Publication bias was assessed by Egger's test.</p> <p> <italic>Results</italic>: Eight relevant articles with a total of 10 534 IBD patients [6785 Crohn's disease (CD), 3713 ulcerative colitis (UC) and 36 indeterminate colitis (IC)] and 6755 healthy controls were included in the meta-analysis, which consisted of 12 studies, 12 for CD, 10 for UC, 2 for IC. There was no significant association between rs2043211 polymorphism and IBD, CD, and IC in overall population. However, stratified meta-analysis by ethnicity showed significant association between rs2043211 polymorphism and CD in the European population under the dominant model [odds ratio (OR) = 1.210, 95% confidence interval (CI) = 1.013–1.445, <italic>p</italic> = 0.036] and homozygote contrast (OR = 1.212, 95% CI = 1.005–1.461, <italic>p</italic> = 0.044).</p> <p> <italic>Conclusions</italic>: Our meta-analysis results indicated significant association between rs2043211 polymorphism and the susceptibility to CD under the dominant model and homozygote contrast in the European population.</p> </abstract>