Cognitive profile of LRRK2‐related Parkinson's disease. Issue 5 (4th February 2015)

• Record Type: Journal Article
• Authors: Srivatsal, Sindhu; Cholerton, Brenna; Leverenz, James B.; Wszolek, Zbigniew K.; Uitti, Ryan J.; Dickson, Dennis W.; Weintraub, Daniel; Trojanowski, John Q.; Van Deerlin, Vivianna M.; Quinn, Joseph F.; Chung, Kathryn A.; Peterson, Amie L.; Factor, Stewart A.; Wood‐Siverio, Cathy; Goldman, Jennifer G.; Stebbins, Glenn T.; Bernard, Bryan; Ritz, Beate; Rausch, Rebecca; Espay, Alberto J.; Revilla, Fredy J.; Devoto, Johnna; Rosenthal, Liana S.; Dawson, Ted M.; Albert, Marilyn S.; Mata, Ignacio F.; Hu, Shu‐Ching; Montine, Kathleen S.; Johnson, Catherine; Montine, Thomas J.; Edwards, Karen L.; Zhang, Jing; Zabetian, Cyrus P.;
• Is Part Of: Movement disorders. Volume 30:Issue 5(2015)
• Page Start: 728
• Page End: 733
• Publication Date: 2015-02-04
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26161
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="mds26161-sec-0001" sec-type="section"> <title>Background</title> <p>Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the <italic>LRRK2</italic> gene are the most common cause of monogenic PD; however, the cognitive profile of <italic>LRRK2</italic>‐related PD is not well‐characterized.</p> </sec> <sec id="mds26161-sec-0002" sec-type="section"> <title>Methods</title> <p>A cohort of 1, 447 PD patients enrolled in the PD Cognitive Genetics Consortium was screened for <italic>LRRK2</italic> mutations and completed detailed cognitive testing. Associations between mutation carrier status and cognitive test scores were assessed using linear regression models.</p> </sec> <sec id="mds26161-sec-0003" sec-type="section"> <title>Results</title> <p> <italic>LRRK2</italic> mutation carriers (n = 29) demonstrated better performance on the Mini Mental State Examination (<italic>P</italic> = 0.03) and the Letter‐Number Sequencing Test (<italic>P</italic> = 0.005). A smaller proportion of <italic>LRRK2</italic> carriers were demented (<italic>P</italic> = 0.03).</p> </sec> <sec id="mds26161-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our cross‐sectional study demonstrates better performance on certain cognitive tests, as well as lower rates of dementia in <italic>LRRK2</italic>‐related PD. Future longitudinal studies are needed to determine whether <italic>LRRK2</italic> mutation carriers exhibit slower cognitive decline. © 2015 International Parkinson and Movement Disorder Society</p> </sec> </abstract>