Magnitude of Cognitive Dysfunction in Adults with Type 2 Diabetes: A Meta-analysis of Six Cognitive Domains and the Most Frequently Reported Neuropsychological Tests Within Domains. (20th February 2014)

• Record Type: Journal Article
• Authors: Palta, Priya; Schneider, Andrea L.C.; Biessels, Geert Jan; Touradji, Pegah; Hill-Briggs, Felicia
• Is Part Of: Journal of the International Neuropsychological Society. Volume 20:Number 3(2014:Mar.)
• Page Start: 278
• Page End: 291
• Publication Date: 2014-02-20
• Subjects: Neuropsychology -- Periodicals; 616.8
• DOI: 10.1017/S1355617713001483
• Languages: English
• ISSNs: 1355-6177

Abstract

<abstract abstract-type="normal"> <title>Abstract</title> <p>The objectives were to conduct a meta-analysis in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards to determine effect sizes (Cohen's <italic>d</italic>) for cognitive dysfunction in adults with type 2 diabetes, relative to nondiabetic controls, and to obtain effect sizes for the most commonly reported neuropsychological tests within domains. Twenty-four studies, totaling 26, 137 patients (<italic>n</italic> = 3351 with diabetes), met study inclusion criteria. Small to moderate effect sizes were obtained for five of six domains: motor function (3 studies, <italic>n</italic> = 2374; <italic>d</italic> = −0.36), executive function (12 studies, <italic>n</italic> = 1784; <italic>d</italic> = −0.33), processing speed (16 studies, <italic>n</italic> = 3076; <italic>d</italic> = −0.33), verbal memory (15 studies, <italic>n</italic> = 4, 608; <italic>d</italic> = −0.28), and visual memory (6 studies, <italic>n</italic> = 1754; <italic>d</italic> = −0.26). Effect size was smallest for attention/concentration (14 studies, <italic>n</italic> = 23, 143; <italic>d</italic> = −0.19). The following tests demonstrated the most notable performance decrements in diabetes samples: Grooved Pegboard (dominant hand) (<italic>d</italic> = −0.60), Rey Auditory Verbal Learning Test (immediate) (<italic>d</italic> = −0.40), Trails B (<italic>d</italic> = −0.39), Rey-Osterreith Complex Figure (delayed) (<italic>d</italic> = −0.38), Trails A (<italic>d</italic> = −0.34), and Stroop Part I (<italic>d</italic> = −0.28). This study provides effect sizes to power future epidemiological and clinical diabetes research studies examining cognitive function and to help inform the selection of neuropsychological tests. (<italic>JINS</italic>, 2014, <italic>20</italic>, 1–14)</p> </abstract>