Demography and treatment response in patients with predominant non‐erosive reflux disease or functional dyspepsia. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Miwa, Hiroto; Haruma, Ken; Sakamoto, Shigeru; Sanada, Katsuyuki; Hiroi, Shinzo; Kinoshita, Yoshikazu
• Is Part Of: Journal of gastroenterology and hepatology. Volume 30:Issue 5(2015:May)
• Page Start: 834
• Page End: 841
• Publication Date: 2015-05
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12877
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12877-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>Non‐erosive reflux disease (NERD) and functional dyspepsia (FD) share some common features, and the appropriateness of managing these diseases independently has been questioned. A post‐hoc subgroup analysis of the LEGEND study was performed to compare demographics and treatment response between patients with NERD and patients with FD.</p> </sec> <sec id="jgh12877-sec-0002" sec-type="section"> <title>Methods</title> <p>Patients with reflux and dyspepsia symptoms who had no endoscopic evidence of mucosal breaks and/or erosions were included and divided into groups with predominant NERD (<italic>n</italic> = 1546) or FD (<italic>n</italic> = 614). Patients received lansoprazole for 4 weeks, and their symptoms were evaluated using questionnaires.</p> </sec> <sec id="jgh12877-sec-0003" sec-type="section"> <title>Results</title> <p>FD patients were significantly younger than NERD patients (54 <italic>vs</italic> 60 years), more likely to have a body mass index < 25 kg/m<sup>2</sup> (72.4% <italic>vs</italic> 67.1%), less likely to have a hiatal hernia (24.0% <italic>vs</italic> 31.2%), and more likely to feel continuous stress (54.7% <italic>vs</italic> 48.0%). After 4 weeks of treatment, > 60% of both patients reported an improvement in reflux symptoms and in most dyspepsia symptoms. The improvement rate for reflux symptoms was lower in FD patients than in NERD patients (<italic>P</italic> < 0.05), whereas the improvement rate for dyspepsia symptoms did not differ between patient groups.</p> </sec> <sec id="jgh12877-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Although no clinically significant differences in pathophysiology exist between NERD and FD, there are some between‐group differences in demographic characteristics and improvement rates for reflux symptoms after treatment with lansoprazole. It remains to be discussed whether it is necessary to make a strict differential diagnosis between these two conditions.</p> </sec> </abstract>