Prostate‐specific membrane antigen‐based imaging in prostate cancer: Impact on clinical decision making process. Issue 7 (18th January 2015)

• Record Type: Journal Article
• Authors: Demirkol, Mehmet Onur; Acar, Ömer; Uçar, Burcu; Ramazanoğlu, Sultan Rana; Sağlıcan, Yeşim; Esen, Tarık
• Is Part Of: Prostate. Volume 75:Issue 7(2015)
• Page Start: 748
• Page End: 757
• Publication Date: 2015-01-18
• Subjects: Prostate -- Diseases -- Periodicals; 616
• DOI: 10.1002/pros.22956
• Languages: English
• ISSNs: 0270-4137

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="pros22956-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>There is an ongoing need for an accurate imaging modality which can be used for staging purposes, metastatic evaluation, predicting biologic aggresiveness and investigating recurrent disease in prostate cancer. Prostate specific membrane antigen, given its favorable molecular characteristics, holds a promise as an ideal target for prostate cancer‐specific nuclear imaging. In this study, we evaluated our initial results of PSMA based PET/CT imaging in prostate cancer.</p> </sec> <sec id="pros22956-sec-0002" sec-type="section"> <title>METHODS</title> <p>A total of 22 patients with a median age and serum PSA level of 68 years and 4.15 ng/ml, respectively underwent Ga‐68 PSMA PET/CT in our hospital between Februrary and August 2014. Their charts were retrospectively reviewed in order to document the clinical characteristics, the indications for and the results of PSMA based imaging and the impact of Ga‐68 PSMA PET/CT findings on disease management.</p> </sec> <sec id="pros22956-sec-0003" sec-type="section"> <title>RESULTS</title> <p>The most common indications were rising PSA after local ± adjuvant treatment followed by staging and metastatic evaluation before definitive or salvage treatment. All except 2 patients had prostatic ± extraprostatic PSMA positive lesions. For those who had a positive result; treatment strategies were tailored accordingly. Above the PSA level of 2 ng/ml, none of the PSMA based nuclear imaging studies revealed negative results.</p> </sec> <sec id="pros22956-sec-0004" sec-type="section"> <title>CONCLUSIONS</title> <p>PSMA based nuclear imaging has significantly impacted our way of handling patients with prostate cancer. Its preliminary performance in different clinical scenarios and ability to detect lesions even in low PSA values seems fairly promising and deserves to be supplemented with further clinical studies. <italic>Prostate 75:748–757, 2015</italic>. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>