Vitamin B12-loaded solid lipid nanoparticles as a drug carrier in cancer therapy. (May 2015)

• Record Type: Journal Article
• Authors: Genç, Lütfi; Kutlu, H. Mehtap; Güney, Gamze
• Is Part Of: Pharmaceutical development and technology. Volume 20:Number 3(2015)
• Page Start: 337
• Page End: 344
• Publication Date: 2015-05
• Subjects: Drug delivery systems -- Periodicals; Pharmaceutical technology -- Periodicals; Drugs -- Administration -- Research -- Periodicals; Drug Delivery Systems -- Periodicals; Pharmaceutical Preparations -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615
• DOI: 10.3109/10837450.2013.867447
• Languages: English
• ISSNs: 1083-7450

Abstract

<abstract> <title>Abstract</title> <p>Nanostructure-mediated drug delivery, a key technology for the realization of nanomedicine, has the potential to improve drug bioavailability, ameliorate release deviation of drug molecules and enable precision drug targeting. Due to their multifunctional properties, solid lipid nanoparticles (SLNs) have received great attention of scientists to find a solution to cancer. Vitamin supplements may contribute to a reduction in the risk of cancer. Vitamin B₁₂ has several characteristics that make it an attractive entity for cancer treatment and possible therapeutic applications. The aim of this study was to produce B₁₂-loaded SLNs (B₁₂-SLNs) and determine the cytotoxic effects of B₁₂-SLNs on H-<italic>R</italic>as 5RP7 and NIH/3T3 control cell line. Results obtained by MTT assay, transmission electron and confocal microscopy showed that B₁₂-loaded SLNs are more effective than free vitamin B₁₂ on cancer cells. In addition, characterization studies indicate that while the average diameter of the B₁₂ was about 650 nm, B₁₂-SLNs were about 200 nm and the drug release efficiency of vit. B₁₂ by means of SLNs increased up to 3 h. These observations point to the fact that B₁₂-SLNs could be used as carrier systems due to the therapeutic effects on cancer.</p> </abstract>