Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder. Issue 4 (13th February 2015)

• Record Type: Journal Article
• Authors: Traks, Tanel; Koido, Kati; Balõtšev, Roman; Eller, Triin; Kõks, Sulev; Maron, Eduard; Tõru, Innar; Shlik, Jakov; Vasar, Eero; Vasar, Veiko
• Is Part Of: Brain and behavior. Volume 5:Issue 4(2015:Apr.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-02-13
• Subjects: Neurology -- Periodicals; Neurosciences -- Periodicals; Psychology -- Periodicals; Psychiatry -- Periodicals; 616.8005
• DOI: 10.1002/brb3.314
• Languages: English
• ISSNs: 2162-3279

Abstract

<abstract abstract-type="main" id="brb3314-abs-0001"> <title>Abstract</title> <sec id="brb3314-sec-0001" sec-type="section"> <title>Background</title> <p>The immune system has been increasingly implicated in the development of mood and anxiety disorders. Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (<italic>IKBKE</italic>) gene encodes IKK<italic>ε</italic> protein that is involved in innate immunity, predominantly antiviral response generation. It also bears pro‐inflammatory properties that could affect psychiatric outcomes. In order to investigate the possible role of <italic>IKBKE</italic> gene in major depressive disorder (MDD) and panic disorder (PD), we conducted a case–control genetic association study concerning these disorders.</p> </sec> <sec id="brb3314-sec-0002" sec-type="section"> <title>Methods</title> <p>In all, 14 SNPs of <italic>IKBKE</italic> gene were genotyped in groups of 391 patients with MDD and 190 patients with PD together with respective 389 and 371 healthy control individuals. The given groups were further divided by gender for additional analyses.</p> </sec> <sec id="brb3314-sec-0003" sec-type="section"> <title>Results</title> <p>Substantial genetic associations were revealed between <italic>IKBKE</italic> SNPs and MDD (multiple testing adjusted <italic>P</italic> < 0.05) and suggestive associations in case of PD (<italic>P</italic><sub>adj</sub> > 0.05). In addition, two SNPs that were only associated with PD among males, also displayed significantly different allele frequencies compared to PD females. This may indicate a specific role of these SNPs in male PD, but caution should be applied here due to the small size of the studied PD males group.</p> </sec> <sec id="brb3314-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The results of this study confirm our initial findings and indicate a possible role of <italic>IKBKE</italic> gene in mood and anxiety disorders.</p> </sec> </abstract>