A Highly Efficient New T1 MRI Contrast Agent with r2/r1 ≈ 1.0: Mixed Cu(II)/Gd(III) Oxide Nanoparticle. (17th March 2015)

• Record Type: Journal Article
• Authors: Bony, Badrul Alam; Baeck, Jong Su; Chang, Yongmin; Bae, Ji Eun; Chae, Kwon Seok; Lee, Gang Ho
• Is Part Of: Bulletin of the Korean Chemical Society. Volume 36:Number 4(2015:Apr.)
• Page Start: 1203
• Page End: 1208
• Publication Date: 2015-03-17
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1002/bkcs.10230
• Languages: English
• ISSNs: 0253-2964

Abstract

<abstract abstract-type="main" id="bkcs10230-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="bkcs10230-para-0001">An ideal <italic>T</italic>₁ MRI contrast agent should have a large <italic>r</italic>₁ value and <italic>r</italic>₂/<italic>r</italic>₁ ratio, which is close to 1. In this study, a new approach to accomplish this is presented using the mixed Cu(II)/Gd(III) oxide nanoparticle. The <sc>d</sc>‐glucuronic acid‐coated Cu(II)/Gd(III) oxide nanoparticle showed <italic>r</italic>₁ = 13.78 mM⁻¹ s⁻¹ and <italic>r</italic>₂ = 14.48 mM⁻¹ s⁻¹ (<italic>r</italic>₂/<italic>r</italic>₁ = 1.05). This result is due to reduced magnetization of mixed nanoparticle resulting from mixing of nearly nonmagnetic Cu(II) into the nanoparticle. This result shows that the <sc>d</sc>‐glucuronic acid–coated Cu(II)/Gd(III) oxide nanoparticle is a potential <italic>T</italic>₁ MRI contrast agent.</p> </abstract>