Strontium hydroxyapatite in situ gel‐forming system – a new approach for minimally invasive bone augmentation. Issue 5 (9th July 2014)

• Record Type: Journal Article
• Authors: Hao, J.; Chou, J.; Kuroda, S.; Otsuka, M.; Kasugai, S.; Lang, N. P.
• Is Part Of: Clinical oral implants research. Volume 26:Issue 5(2015:May)
• Page Start: 581
• Page End: 585
• Publication Date: 2014-07-09
• Subjects: Dental implants -- Research -- Periodicals; 617.69
• DOI: 10.1111/clr.12446
• Languages: English
• ISSNs: 0905-7161

Abstract

<abstract abstract-type="main" id="clr12446-abs-0001"> <title>Abstract</title> <sec id="clr12446-sec-0001" sec-type="section"> <title>Objectives</title> <p>To achieve ideal functional and aesthetic requirements, ridge augmentation is often required before dental implant placement. Bone augmentation (especially vertical), which normally consists of complex and invasive surgeries, still remains challenge. This study seeks to investigate the feasibility of an injectable <italic>in situ</italic> gel‐forming system containing strontium hydroxyapatite (SrHA) and alginate for minimally invasive bone augmentation in a rat calvarial model.</p> </sec> <sec id="clr12446-sec-0002" sec-type="section"> <title>Material and methods</title> <p>SrHA–alginate solution was prepared by mixing SrHA powder with alginate solution (20 mg/mL) to the final concentration of 0.5% (w/v). Each animal received a 200‐μL single subperiosteal injection of either SrHA–alginate solution or alginate solution. The new bone formation was assessed at 0, 4, and 8 weeks histologically and radiologically.</p> </sec> <sec id="clr12446-sec-0003" sec-type="section"> <title>Results</title> <p>The SrHA–alginate solution materials could form solid gel once injected. As such, no sutures were required to close the injection site. Significantly greater amount of new bone formation was observed in the SrHA–alginate group compared with the alginate group both by micro‐CT and by histological section. The newly formed bone in the SrHA–alginate group originated both from the underlying original bone and from the elevated periosteum. A 2.3‐fold increase of the vertical bone height was observed in the SrHA–alginate group compared with 1.3‐fold increase in the alginate group.</p> </sec> <sec id="clr12446-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Rat calvarial bone augmentation was achieved by a single subperiosteal injection of SrHA–alginate solution without any administration of stem cells or growth factors. The <italic>in situ</italic> gel‐forming material may hold potential therapeutic benefits for local bone augmentation in a minimally invasive manner.</p> </sec> </abstract>