Clinical efficacy of peramivir in adult patients with seasonal influenza during the winter of 2012 in Japan. (6th May 2014)

• Record Type: Journal Article
• Authors: Yoshino, Yusuke; Seo, Kazunori; Koga, Ichiro; Kitazawa, Takatoshi; Ota, Yasuo
• Is Part Of: Clinical respiratory journal. Volume 9:Number 2(2015)
• Page Start: 228
• Page End: 232
• Publication Date: 2014-05-06
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 616.24
• DOI: 10.1111/crj.12129
• Languages: English
• ISSNs: 1752-6981

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="crj12129-sec-0001" sec-type="section"> <title>Background</title> <p>Peramivir is an intravenously administered neuraminidase inhibitor for influenza. The clinical efficacy of peramivir remains unclear because it is used in a limited number of countries. We compared the clinical efficacy of peramivir with that of oseltamivir in influenza patients during the 2012–2013 season.</p> </sec> <sec id="crj12129-sec-0002" sec-type="section"> <title>Methods</title> <p>Thirty‐two influenza patients who were hospitalized at Teikyo University Hospital, a teaching hospital in Tokyo, Japan, from October 2012 to March 2013 were enrolled. Among them, 23 and 9 were treated with peramivir and oseltamivir, respectively. The end points of this study were the time to defervescence and survival rate.</p> </sec> <sec id="crj12129-sec-0003" sec-type="section"> <title>Results</title> <p>There were no significant differences in the clinical backgrounds of the two groups. However, patients treated with peramivir tended to have a higher incidence of consciousness disturbance [34.8% (8/23) vs 0.00% (0/9), <italic>P</italic> = 0.064]. There were no significant differences between the peramivir and oseltamivir groups with respect to the time to defervescence (30.9 ± 18.7 h vs 34.7 ± 18.6 h) or survival rate [95.7% (22/23) vs 100% (9/9), respectively].</p> </sec> <sec id="crj12129-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The clinical efficacy of peramivir is non‐inferior to that of oseltamivir, although peramivir tended to be used in patients with serious complications. Intravenous administration of peramivir may be useful for patients with serious complications, such as consciousness disturbances.</p> </sec> </abstract>