A Randomized, Double‐Blind, Crossover Study to Evaluate the Depth Response Relationship of Intradermal Capsaicin‐Induced Pain and Hyperalgesia in Healthy Adult Volunteers. Issue 4 (19th December 2014)

• Record Type: Journal Article
• Authors: Silberberg, Alan; Moeller‐Bertram, Tobias; Wallace, Mark S.
• Is Part Of: Pain medicine. Volume 16:Issue 4(2015)
• Page Start: 745
• Page End: 752
• Publication Date: 2014-12-19
• Subjects: Pain -- Periodicals; Pain -- Treatment -- Periodicals; Analgesics -- Periodicals; Pain -- Periodicals; Pain Management -- Periodicals; Douleur -- Périodiques; Douleur -- Traitement -- Périodiques; Analgésiques -- Périodiques; Analgésique; Soulagement de la douleur; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.047205
• DOI: 10.1111/pme.12639
• Languages: English
• ISSNs: 1526-2375

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="pme12639-sec-0001" sec-type="section"> <title>Objective</title> <p>The purpose of this study was to evaluate pain and hyperalgesia in response to different depths of intradermal (ID) capsaicin injections in healthy volunteers.</p> </sec> <sec id="pme12639-sec-0002" sec-type="section"> <title>Design</title> <p>Double‐blind, cross‐over study.</p> </sec> <sec id="pme12639-sec-0003" sec-type="section"> <title>Setting</title> <p>Clinical Research Laboratory.</p> </sec> <sec id="pme12639-sec-0004" sec-type="section"> <title>Subjects</title> <p>Fifteen healthy male subjects received ID capsaicin injections into the volar aspect of each forearm at depths of 1 mm, 3 mm, 5 mm, and 7 mm. After injection, spontaneous pain, elicited pain, flare response, heat thresholds, and area of hyperalgesia were measured at various time points.</p> </sec> <sec id="pme12639-sec-0005" sec-type="section"> <title>Outcomes Measure</title> <p>Spontaneous pain, elicited pain (pinprick, stroking, and hot pain), hyperalgesia area, and allodynia area.</p> </sec> <sec id="pme12639-sec-0006" sec-type="section"> <title>Results</title> <p>No significant difference was found between any depths in spontaneous pain, elicited pain (pinprick, stroking, hot pain), hyperalgesia area, or allodynia area. A significant difference was found in the change in heat threshold between 5 mm and 1 mm, 7 mm and 1 mm, 5 mm and 3 mm, 7 mm and 3 mm depths. A significant difference was found in flare area between 5 mm and 3 mm depths. A significant difference was found in systolic blood pressure area under the curve (AUC) between 7 mm and 1 mm depths, and for both systolic and diastolic pressures for 5 mm and 1 mm depths, and 5 mm and 3 mm depths. A significant difference was found in pulse AUC between 5 mm and 1 mm depths and 5 mm and 3 mm depths.</p> </sec> <sec id="pme12639-sec-0007" sec-type="section"> <title>Conclusions</title> <p>Injection of capsaicin at different depths in the skin had different effects on heart rate and blood pressure but no effect on pain. These results may have implications on the pharmacology and analgesic predictive value of the model of ID capsaicin.</p> </sec> </abstract>