Mortality in Parkinson's disease: A 38‐year follow‐up study. Issue 2 (1st December 2014)

• Record Type: Journal Article
• Authors: Pinter, Bernadette; Diem‐Zangerl, Anja; Wenning, Gregor Karl; Scherfler, Christoph; Oberaigner, Willi; Seppi, Klaus; Poewe, Werner; Stacy (Chair), Mark; Lang, Anthony; Napier, Celeste; Samuel, Michael; Strafella, Antonio; Weintraub, Daniel
• Is Part Of: Movement disorders. Volume 30:Issue 2(2015)
• Page Start: 266
• Page End: 269
• Publication Date: 2014-12-01
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26060
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="mds26060-sec-0001" sec-type="section"> <title>Background</title> <p>In this study we report on the outcome including overall and cause‐specific mortality of Parkinson's disease (PD) patients subsequent to 38 years of surveillance. This is an extension study of our previous report on mortality.</p> </sec> <sec id="mds26060-sec-0002" sec-type="section"> <title>Methods</title> <p>Two hundred thirty‐seven patients with a symptom onset between 1974 and 1984 were followed until the date of December 31, 2012 or death, representing a follow‐up period of up to 38 years. Overall and cause‐specific standardized mortality ratios (SMRs) were calculated, and predictors for survival at disease onset were estimated.</p> </sec> <sec id="mds26060-sec-0003" sec-type="section"> <title>Results and Conclusion</title> <p>Two hundred thirty patients had died by December 31, 2012; a total of 3, 489 person‐years were available for observation. The SMR at 38 years of follow‐up was 2.02 (1.76‐2.29). Employing Cox's proportional hazard modeling, male sex, gait disorder, absence of classical rest tremor, and absence of asymmetry predicted poor survival in this cohort. Increased cause‐specific SMRs were found for pneumonia and cerebrovascular and cardiovascular diseases. © 2014 International Parkinson and Movement Disorder Society</p> </sec> </abstract>