Noncoding RNA blockade of autophagy is therapeutic in medullary thyroid cancer. (8th December 2014)

• Record Type: Journal Article
• Authors: Gundara, Justin S.; Zhao, JingTing; Gill, Anthony J.; Lee, James C.; Delbridge, Leigh; Robinson, Bruce G.; McLean, Catriona; Serpell, Jonathan; Sidhu, Stan B.
• Is Part Of: Cancer medicine. Volume 4:Number 2(2015:Feb.)
• Page Start: 174
• Page End: 182
• Publication Date: 2014-12-08
• Subjects: 616.994005
• DOI: 10.1002/cam4.355
• Languages: English
• ISSNs: 2045-7634

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="cam4355-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p>(A) western blot of apoptosis and autophagy markers 48 h post TT cell transfection with miR‐9‐3p or negative control; (B) quantified densitometry results of 2A; (C) western blot of apoptosis and autophagy markers 48h post MZ‐CRC‐1 cell transfection with miR‐9‐3p or negative control; (D) quantified densitometry results of 2C (#: P &lt; 0.05). These results indicate that autophagy is a tumor cell survival mechanism in medullary thyroid carcinoma (MTC) that when disabled, is of therapeutic advantage. Beclin‐1 expression may be a useful prognostic biomarker of aggressive disease. <boxed-text content-type="graphic" id="cam4355-blkfxd-0001" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjf84qwm2" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>