Elucidating pH‐Dependent Collagen Triple Helix Formation through Interstrand Hydroxyproline‐Glutamic Acid Interactions. Issue 3 (21st December 2014)

• Record Type: Journal Article
• Authors: Chen, Liwei; Cai, Shuting; Lim, Jaehong; Lee, Su Seong; Lee, Song‐Gil
• Is Part Of: Chembiochem. Volume 16:Issue 3(2015)
• Page Start: 407
• Page End: 410
• Publication Date: 2014-12-21
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201402570
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Here, we describe systematic explorations into the molecular basis underlying hydroxyproline‐mediated interstrand interactions on the triple‐helical stability of collagen‐mimetic peptides containing glutamic acid residues. Our studies reveal that the triple‐helical stability of these peptides relies on the existence of interstrand interactions between hydroxyprolines and glutamic acid residues that are pH dependent. These unique interactions have been used to engineer collagen peptides that form triple helices on demand through pH control.</p> </abstract>