Comparison of plasma vitamin D levels in patients with Sjögren's syndrome and healthy subjects. (28th January 2014)

• Record Type: Journal Article
• Authors: Erten, Şükran; Şahin, Ali; Altunoğlu, Alpaslan; Gemcioğlu, Emin; Koca, Cemile
• Is Part Of: International journal of rheumatic diseases. Volume 18:Number 1(2015)
• Page Start: 70
• Page End: 75
• Publication Date: 2014-01-28
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.12298
• Languages: English
• ISSNs: 1756-1841

Abstract

<abstract abstract-type="main" id="apl12298-abs-0001"> <title>Abstract</title> <sec id="apl12298-sec-0001" sec-type="section"> <title>Aim</title> <p>Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by chronic inflammation of the salivary and lacrimal glands. There is increasing evidence indicating that vitamin D is important in the initiation and propogation of a range of autoimmune diseases which may include SS. The aim of the present study was to evaluate plasma vitamin D (vit D) levels in patients with SS and to compare this with a control group.</p> </sec> <sec id="apl12298-sec-0002" sec-type="section"> <title>Method</title> <p>One hundred and seven SS patients (97 [90.7%] female and 10 [9.3%] male) and 74 healthy controls (64 [86.5%] female and 10 [13.5%] male) were included into the study. Plasma baseline 25‐hydroxy‐vit D levels were measured by high‐powered liquid chromatography method using an Agilent 1100 liquid chromatograph.</p> </sec> <sec id="apl12298-sec-0003" sec-type="section"> <title>Results</title> <p>Plasma vit D levels in SS patients (20.5 ± 10.5 μg/L) were significantly lower than in the control group (28.4 ± 15.2 μg/L) (<italic>P</italic> < 0.001). Female SS patients had significanly lower vit D levels (19.3 ± 9.3 μg/L) than controls (28.3 ± 15.8 μg/L) (<italic>P</italic> < 0.001) but this difference was not present among the male patients and controls. There was no correlation between plasma vit D levels and erythrocyte sedimentation rate and C‐reactive protein in SS patients.</p> </sec> <sec id="apl12298-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Vit D deficiency was frequent in patients with SS. In particular, female SS patients had the risk of vit D deficiency. It may be convenient to look for vit D deficiency and to correct vit D nutritional status in SS patients.</p> </sec> </abstract>