Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T‐Cell Activation. Issue 13 (12th January 2015)

• Record Type: Journal Article
• Authors: Meyer, Randall A.; Sunshine, Joel C.; Perica, Karlo; Kosmides, Alyssa K.; Aje, Kent; Schneck, Jonathan P.; Green, Jordan J.
• Is Part Of: Small. Volume 11:Issue 13(2015)
• Page Start: 1519
• Page End: 1525
• Publication Date: 2015-01-12
• Subjects: Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201402369
• Languages: English
• ISSNs: 1613-6810

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="smll201402369-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Non‐spherical nanodimensional artificial antigen presenting cells</bold> (naAPCs) offer the potential to systemically induce an effective antigen‐specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T‐Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non‐specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjf4nq77w" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>