Impact of regular physical activity on blood glucose control and cardiovascular risk factors in adolescents with type 2 diabetes mellitus – a multicenter study of 578 patients from 225 centres. Issue 3 (2nd June 2014)

• Record Type: Journal Article
• Authors: Herbst, A; Kapellen, T; Schober, E; Graf, C; Meissner, T; Holl, RW; for the DPV‐Science‐Initiative
• Is Part Of: Pediatric diabetes. Volume 16:Issue 3(2015:May)
• Page Start: 204
• Page End: 210
• Publication Date: 2014-06-02
• Subjects: Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.12144
• Languages: English
• ISSNs: 1399-543X

Abstract

<abstract abstract-type="main" id="pedi12144-abs-0001"> <title>Abstract</title> <sec id="pedi12144-sec-0001" sec-type="section"> <title>Introduction</title> <p id="pedi12144-para-0001">Regular physical activity (RPA) is a major therapeutic recommendation in children and adolescents with type 2 diabetes mellitus (T2DM). We evaluated the association between frequency of RPA and metabolic control, cardiovascular risk factors, and treatment regimes.</p> </sec> <sec id="pedi12144-sec-0002" sec-type="section"> <title>Methods</title> <p id="pedi12144-para-0002">The Pediatric Quality Initiative (DPV), including data from 225 centers in Germany and Austria, provided anonymous data of 578 patients (10–20 yr; mean 15.7 ± 2.1 yr; 61.9% girls) with T2DM. Patients were grouped by the frequency of their self‐reported RPA per week: RPA 0, none; RPA 1, 1–2×/wk; RPA 2, >2×/wk.</p> </sec> <sec id="pedi12144-sec-0003" sec-type="section"> <title>Results</title> <p id="pedi12144-para-0003">The frequency of RPA ranged from 0 to 9×/wk (mean 1.1×/wk ±1.5). 55.7% of the patients reported no RPA (58.1% of the girls). Hemoglobin A1c (HbA1c) differed significantly among RPA groups (p < 0.002), being approximately 0.8 percentage points lower in RPA 2 compared to RPA 0. Body mass index (BMI‐SDS) was higher in the groups with less frequent RPA (p < 0.00001). Multiple regression analysis revealed a negative association between RPA and HbA1c (p < 0.0001) and between RPA and BMI‐SDS (p < 0.01). The association between RPA and high density lipoprotein (HDL)‐cholesterol was positive (p < 0.05), while there was no association to total cholesterol, low density lipoprotein (LDL)‐cholesterol or triglycerides. Approximately 80% of the patients received pharmacological treatment (oral antidiabetic drugs and/or insulin) without differences between RPA groups.</p> </sec> <sec id="pedi12144-sec-0004" sec-type="section"> <title>Conclusion</title> <p id="pedi12144-para-0004">More than half of the adolescents with T2DM did not perform RPA. Increasing physical activity was associated with a lower HbA1c, a lower BMI‐SDS, a higher HDL‐cholesterol, but not with a difference in treatment regime. These results suggest that regular exercise is a justified therapeutic recommendation for children and adolescents with T2DM.</p> </sec> </abstract>