Prevalent and up‐regulated vimentin expression in micropapillary components of lung adenocarcinomas and its adverse prognostic significance. (11th February 2015)

• Record Type: Journal Article
• Authors: Nakashima, Hiroyasu; Jiang, Shi‐Xu; Sato, Yuichi; Hoshi, Keika; Matsumoto, Toshihide; Nagashio, Ryo; Kobayashi, Makoto; Matsuo, Yukiko; Shiomi, Kazu; Hayakawa, Kazushige; Saegusa, Makoto; Satoh, Yukitoshi
• Is Part Of: Pathology international. Volume 65:Number 4(2015:Apr.)
• Page Start: 183
• Page End: 192
• Publication Date: 2015-02-11
• Subjects: Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12257
• Languages: English
• ISSNs: 1320-5463

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The factors conferring the increased malignancy on lung adenocarcinoma with micropapillary component (AC‐MPC) remain to be elucidated. On proteomics based on 2‐dimensional gel electrophoresis, 19 proteins differentially expressed by more than 1.5‐fold between AC‐MPC and conventional adenocarcinoma (CAC); in particular, vimentin, one of the proteins, was 3.5‐fold up‐regulated in AC‐MPC. Subsequent semi‐quantitative investigation by immunohistochemistry with large cohorts comprised 101 AC‐MPC and 119 CAC, respectively, of different stages revealed that vimentin was expressed in MPC of 95 (94.1%) AC‐MPC and the expression scores were higher than those of well‐ and moderately differentiated CAC, as well as the background non‐MPC of the AC‐MPC (<italic>P</italic> < 0.0001), but not significantly different from those of poorly differentiated CAC (<italic>P</italic> = 0.561). Even within the AC‐MPC entity, higher vimentin expression was correlated with more frequent vascular invasion and more advanced node metastasis (<italic>P</italic> < 0.02), and multivariate analysis showed that high vimentin expression and worse node statuses were independent indicators of adverse prognosis (<italic>P</italic> < 0.048). In conclusion, vimentin expression is prevalent and markedly up‐regulated in MPC, which might reflect the biological essence of poorer differentiation or dedifferentiation of MPC, and this might have a role in the acquisition and increase of invasiveness and consequent more malignant nature of MPC.</p> </abstract>