Potential associations between perihepatic lymph node enlargement and liver fibrosis, hepatocellular injury or hepatocarcinogenesis in chronic hepatitis B virus infection. Issue 4 (16th June 2014)

• Record Type: Journal Article
• Authors: Sato, Masaya; Hikita, Hiromi; Hagiwara, Shu; Sato, Mamiko; Soroida, Yoko; Suzuki, Atsushi; Gotoh, Hiroaki; Iwai, Tomomi; Kojima, Soichi; Matsuura, Tomokazu; Yotsuyanagi, Hiroshi; Koike, Kazuhiko; Yatomi, Yutaka; Ikeda, Hitoshi
• Is Part Of: Hepatology research. Volume 45:Issue 4(2015:Apr.)
• Page Start: 397
• Page End: 404
• Publication Date: 2014-06-16
• Subjects: Liver -- Diseases -- Periodicals; Liver Diseases -- Periodicals; Foie -- Maladies -- Périodiques; 616.362
• DOI: 10.1111/hepr.12361
• Languages: English
• ISSNs: 1386-6346

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="hepr12361-sec-0001" sec-type="section"> <title>Aim</title> <p>Although perihepatic lymph node enlargement (PLNE) is frequently observed in chronic liver disease, little is known about PLNE in chronic hepatitis B virus (HBV) infection. We aimed to evaluate this issue.</p> </sec> <sec id="hepr12361-sec-0002" sec-type="section"> <title>Methods</title> <p>We originally enrolled a consecutive 502 patients with chronic HBV infection. Among them, 288 patients without history of interferon‐based or nucleoside analog treatment and hepatocellular carcinoma (HCC) were primarily analyzed.</p> </sec> <sec id="hepr12361-sec-0003" sec-type="section"> <title>Results</title> <p>PLNE was detected in 27 of 288 (9.4%) patients, which was fewer than that in chronic hepatitis C patients but more than that in subjects undertaking a general health examination as previously reported. The presence of PLNE was significantly associated with a higher probability of having an aspartate aminotransferase (AST) platelet ratio index of more than 1.5 (11.1% vs 1.5%, <italic>P</italic> = 0.01), a higher AST level (38.0 vs 26.8 U/L, <italic>P</italic> = 0.001), a higher alanine aminotransferase level (50.1 vs 28.0 U/L, <italic>P</italic> < 0.0001), and a lower platelet count (18.6 vs 20.6 × 10<sup>4</sup>/<italic>μ</italic>L, <italic>P</italic> = 0.048) after adjustment for sex and age. However, in our original sample (<italic>n</italic> = 502), PLNE was observed in 1.4% of the patients with HCC and/or its history whereas 9.2% of the patients without HCC, and the proportion was significantly lower in patients with HCC and/or its history (<italic>P</italic> = 0.03).</p> </sec> <sec id="hepr12361-sec-0004" sec-type="section"> <title>Conclusion</title> <p>PLNE was associated with liver fibrosis and hepatocellular injury, but was negatively associated with HCC in chronic HBV infection.</p> </sec> </abstract>