A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis. Issue 5 (25th February 2015)

• Record Type: Journal Article
• Authors: Hsiao, W.‐C.; Shia, K.‐S.; Wang, Y.‐T.; Yeh, Y.‐N.; Chang, C.‐P.; Lin, Y.; Chen, P.‐H.; Wu, C.‐H.; Chao, Y.‐S.; Hung, M.‐S.
• Is Part Of: Diabetes, obesity & metabolism. Volume 17:Issue 5(2015:May)
• Page Start: 495
• Page End: 504
• Publication Date: 2015-02-25
• Subjects: Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.12447
• Languages: English
• ISSNs: 1462-8902

Abstract

<abstract abstract-type="main" id="dom12447-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="dom12447-sec-0001" sec-type="section"> <title>Aim</title> <p id="dom12447-para-0001">To investigate the <italic>in vivo</italic> metabolic effects of treatment with BPR0912, a novel and potent peripheral cannabinoid receptor 1 (CB1R) antagonist, on both normal mice and diet‐induced obese (DIO) mice.</p> </sec> <sec id="dom12447-sec-0002" sec-type="section"> <title>Methods</title> <p id="dom12447-para-0002">The acute peripheral effects of BPR0912 administration on gastrointestinal transit and energy metabolism in normal mice were investigated. The effects of chronic BPR0912 treatment were compared with those of rimonabant using DIO mice. Alterations to body weight and biochemical and metabolic variables were determined.</p> </sec> <sec id="dom12447-sec-0003" sec-type="section"> <title>Results</title> <p id="dom12447-para-0003">Acute treatment with BPR0912 did not alter food intake or energy metabolism, but efficiently reversed CB1R‐mediated gastrointestinal delay. Chronic treatment of DIO mice with BPR0912 showed that BPR0912 exerts a food intake‐independent mechanism, which contributes to weight loss. Genes involved in β‐oxidation and thermogenesis were upregulated in white adipose tissue (WAT) in addition to increased lipolytic activity, whereas Ucp1 expression was induced in brown adipose tissue (BAT) and body temperature was elevated. Expression of the β2‐adrenoceptor was specifically elevated in both WAT and BAT in a manner dependent on the BPR0912 dose. Lastly, chronic BPR0912 treatment was more efficacious than rimonabant in reducing hepatic triglycerides in DIO mice.</p> </sec> <sec id="dom12447-sec-0004" sec-type="section"> <title>Conclusion</title> <p id="dom12447-para-0004">BPR0912 exhibits significant <italic>in vivo</italic> efficacy in inducing food intake‐independent weight loss in DIO mice, while tending to reduce their hepatic steatosis. The thermogenic effects of BPR0912, as well as its modulation of protein and gene expression patterns in WAT and BAT, may enhance its efficacy as an anti‐obesity agent. The results of the present study support the benefits of the use of peripheral CB1R antagonists to combat metabolic disorders.</p> </sec> </abstract>