An investigation study of gelatin release from semi‐interpenetrating polymeric network hydrogel patch for excision wound healing on Wistar rat model. Issue 25 (19th March 2015)

• Record Type: Journal Article
• Authors: Jaiswal, Maneesh; Gupta, Asheesh; Dinda, Amit Kumar; Koul, Veena
• Is Part Of: Journal of applied polymer science. Volume 132:Issue 25(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-03-19
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.42120
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Semi‐interpenetrating polymeric network hydrogel patches are fabricated using poly(acrylamide) (PAm) and gelatin (G) in which poly(caprolactone) diacrylate is used as a crosslinker for PAm while gelatin is kept uncrosslinked. The healing efficiency of selected hydrogel dressing [PAm₁G₁(0.5)] is evaluated in comparison with control group (cotton gauze covered with 3M Tegaderm™). The sustained release of gelatin is found to extend from 4 to 15 days while maximum tensile strength stretched to 559 ± 12.5 kPa in PAm₁G_0.5 matrix, which reduced to 158 ± 6.1 kPa at higher gelatin content (PAm₁G_1.0). The higher wound contraction (34%), less inflammatory response, significant improvement (<italic>P</italic> &lt; 0.05) in the collagen biosynthesis, and the granulation tissue formation are observed in PAm/G treated animals in comparison to control, as evidenced by quantitative enhancement of DNA (21%), hydroxyproline (28%), and hexosamine (41%). The histological examination of PAm/G hydrogel treated wound tissues shows enhanced re‐epithelialization on day 8 and 12 post‐wounding, in comparison to control group. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. <bold>2015</bold>, <italic>132</italic>, 42120.</p> </abstract>