One‐Pot Multi‐Component Synthesis of 1, 4‐Dihydropyridines Using Zn2+@KSF and Evaluating Their Antibacterial and Antioxidant Activities. Issue 4 (24th February 2015)

• Record Type: Journal Article
• Authors: Mahmoodi, Nosrat O.; Ramzanpour, Sahar; Ghanbari Pirbasti, Fateme
• Is Part Of: Archiv der Pharmazie. Volume 348:Issue 4(2015:Apr.)
• Page Start: 275
• Page End: 282
• Publication Date: 2015-02-24
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.201400414
• Languages: English
• ISSNs: 0365-6233

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ardp201400414-sec-0001" sec-type="section"> <p>New 5‐aryl‐10‐(4‐(4‐methoxyphenyl)thiazole‐2‐yl)‐9, 10‐dihydropyrido[2, 3‐d:5, 6‐d′]dipyrimidinone‐2, 4, 6, 8‐(1<italic>H</italic>, 3<italic>H</italic>, 5<italic>H</italic>, 7<italic>H</italic>)‐tetraones <bold>6a</bold>–<bold>d</bold> were synthesized through one‐pot four‐component reaction of aldehydes, barbituric acid, and thiazole using Zn²⁺@KSF under reflux condition. The key features of this reaction are: incorporating four heterocyclic rings, using a heterogeneous and efficient catalyst, high yield, and easy‐to‐setup reaction. The structure of the products was confirmed by FT‐IR, ¹H NMR, and ¹³C NMR spectra. The antibacterial activities of compounds <bold>6a–d</bold> were screened against <italic>Escherichia coli</italic>, <italic>Micrococcus luteus</italic>, <italic>Pseudomonas aeruginosa</italic>, and <italic>Staphylococcus aureus</italic> bacterial strains using the zone inhibition method. Also, the 2, 2‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging activities of compounds <bold>6a–d</bold> were evaluated. All compounds showed good antioxidant capacity in comparison to ascorbic acid. The IC₅₀ values of the antioxidant activity were calculated. The proposed mechanism for antioxidant activity is discussed.</p> </sec> </abstract>