Environment‐Sensitive Fluorescent Probe: A Benzophosphole Oxide with an Electron‐Donating Substituent1. (4th March 2015)

• Record Type: Journal Article
• Authors: Yamaguchi, Eriko; Wang, Chenguang; Fukazawa, Aiko; Taki, Masayasu; Sato, Yoshikatsu; Sasaki, Taeko; Ueda, Minako; Sasaki, Narie; Higashiyama, Tetsuya; Yamaguchi, Shigehiro
• Is Part Of: Angewandte Chemie. Volume 127:Number 15(2015)
• Page Start: 4622
• Page End: 4626
• Publication Date: 2015-03-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201500229
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Electron‐donating aryl groups were attached to electron‐accepting benzophosphole skeletons. Among several derivatives thus prepared, one benzophosphole oxide was particularly interesting, as it retained high fluorescence quantum yields even in polar and protic solvents. This phosphole‐based compound exhibited a drastic color change of its fluorescence spectrum as a function of the solvent polarity, while the absorption spectra remained virtually unchanged. Capitalizing on these features, this phosphole‐based compound was used to stain adipocytes, in which the polarity of subcellular compartments could then be discriminated on the basis of the color change of the fluorescence emission.</p> </abstract>