A Photorhabdus Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase. Issue 5 (25th February 2015)

• Record Type: Journal Article
• Authors: Nollmann, Friederike I.; Heinrich, Antje K.; Brachmann, Alexander O.; Morisseau, Christophe; Mukherjee, Krishnendu; Casanova‐Torres, Ángel M.; Strobl, Frederic; Kleinhans, David; Kinski, Sebastian; Schultz, Katharina; Beeton, Michael L.; Kaiser, Marcel; Chu, Ya‐Yun; Phan Ke, Long; Thanwisai, Aunchalee; Bozhüyük, Kenan A. J.; Chantratita, Narisara; Götz, Friedrich; Waterfield, Nick R.; Vilcinskas, Andreas; Stelzer, Ernst H. K.; Goodrich‐Blair, Heidi; Hammock, Bruce D.; Bode, Helge B.
• Is Part Of: Chembiochem. Volume 16:Issue 5(2015)
• Page Start: 766
• Page End: 771
• Publication Date: 2015-02-25
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201402650
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium <italic>Photorhabdus luminescens</italic>, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.</p> </abstract>