Fat distribution in children and adolescents with myelomeningocele. (23rd September 2014)

• Record Type: Journal Article
• Authors: Mueske, Nicole M; Ryan, Deirdre D; Van Speybroeck, Alexander L; Chan, Linda S; Wren, Tishya AL
• Is Part Of: Developmental medicine & child neurology. Volume 57:Number 3(2015:Mar.)
• Page Start: 273
• Page End: 278
• Publication Date: 2014-09-23
• Subjects: Child development -- Periodicals; Pediatric neurology -- Periodicals; 616.8
• DOI: 10.1111/dmcn.12591
• Languages: English
• ISSNs: 0012-1622

Abstract

<abstract abstract-type="main" id="dmcn12591-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="dmcn12591-sec-0001" sec-type="section"> <title>Aim</title> <p>To evaluate fat distribution in children and adolescents with myelomeningocele using dual‐energy X‐ray absorptiometry (DXA).</p> </sec> <sec id="dmcn12591-sec-0002" sec-type="section"> <title>Method</title> <p>Cross‐sectional DXA measurements of the percentage of fat in the trunk, arms, legs, and whole body were compared between 82 children with myelomeningocele (45 males, 37 females; mean age 9y 8mo, SD 2y 7mo; 22 sacral, 13 low lumbar, 47 mid lumbar and above) and 119 comparison children (65 males, 54 females; mean age 10y 4mo, SD 2y 4mo). Differences in fat distribution between groups were evaluated using univariate and multivariate analyses.</p> </sec> <sec id="dmcn12591-sec-0003" sec-type="section"> <title>Results</title> <p>Children with myelomeningocele had higher total body fat (34% vs 31%, <italic>p</italic>=0.02) and leg fat (42% vs 35%, <italic>p</italic><0.001) than comparison children, but no differences in trunk or arm fat after adjustment for anthropometric measures.</p> </sec> <sec id="dmcn12591-sec-0004" sec-type="section"> <title>Interpretation</title> <p>Children with myelomeningocele have higher than normal total body and leg fat, but only children with higher level lesions have increased trunk fat, which may be caused by greater obesity in this group. Quantifying segmental fat distribution may aid in better assessment of excess weight and, potentially, the associated health risks.</p> </sec> </abstract>