Frontispiece: Cell Penetrating Synthetic Antimicrobial Peptides (SAMPs) Exhibiting Potent and Selective Killing of Mycobacterium by Targeting Its DNA. Issue 9 (23rd February 2015)

• Record Type: Journal Article
• Authors: Sharma, Aashish; Pohane, Amol Arunrao; Bansal, Sandhya; Bajaj, Avinash; Jain, Vikas; Srivastava, Aasheesh
• Is Part Of: Chemistry. Volume 21:Issue 9(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-02-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201580961
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Synthetic Antimicrobial Peptides</bold> Natural antimicrobial peptides are an integral part of the defense mechanism of many organisms. In their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 3540 ff.</ext-link>, A. Bajaj, V. Jain, A. Srivastava et al. report on polyaspartamides that act as non‐membrane‐lytic synthetic antimicrobial peptides (SAMPs), selectively killing <italic>Mycobacterium smegmatis</italic> over <italic>Escherichia coli</italic> or mammalian cells. The antibacterial action is linked to cellular uptake of these SAMPs, which is inhibited in <italic>E. coli</italic> by the lipopolysaccharide (LPS) layer. Upon internalization, the SAMPs interact with the exposed genomic DNA of bacteria, killing the bacteria as a consequence.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjdpnkzk4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>