Chirality‐Assisted Ring‐Like Aggregation of Aβ(1–40) at Liquid–Solid Interfaces: A Stereoselective Two‐Step Assembly Process1. Issue 7 (22nd December 2014)

• Record Type: Journal Article
• Authors: Gao, Guanbin; Zhang, Mingxi; Lu, Pei; Guo, Guanlun; Wang, Dong; Sun, Taolei
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 7(2015)
• Page Start: 2245
• Page End: 2250
• Publication Date: 2014-12-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201410768
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Molecular chirality is introduced at liquid–solid interfaces. A ring‐like aggregation of amyloid Aβ(1–40) on <italic>N</italic>‐isobutyryl‐<sc>L</sc>‐cysteine (<sc>L</sc>‐NIBC)‐modified gold substrate occurs at low Aβ(1–40) concentration, while <sc>D</sc>‐NIBC modification only results in rod‐like aggregation. Utilizing atomic force microscope controlled tip‐enhanced Raman scattering, we directly observe the secondary structure information for Aβ(1–40) assembly in situ at the nanoscale. <sc>D</sc>‐ or <sc>L</sc>‐NIBC on the surface can guide parallel or nonparallel alignment of β‐hairpins through a two‐step process based on electrostatic‐interaction‐enhanced adsorption and subsequent stereoselective recognition. Possible electrostatic interaction sites (R5 and K16) and a chiral recognition site (H14) of Aβ(1–40) are proposed, which may provide insight into the understanding of this effect.</p> </abstract>