Antibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones. Issue 4 (24th February 2015)

• Record Type: Journal Article
• Authors: Pahontu, Elena; Julea, Felicia; Rosu, Tudor; Purcarea, Victor; Chumakov, Yurie; Petrenco, Petru; Gulea, Aurelian
• Is Part Of: Journal of cellular and molecular medicine. Volume 19:Issue 4(2015)
• Page Start: 865
• Page End: 878
• Publication Date: 2015-02-24
• Subjects: Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.12508
• Languages: English
• ISSNs: 1582-1838

Abstract

<abstract abstract-type="main" id="jcmm12508-abs-0001"> <title>Abstract</title> <p>1‐phenyl‐3‐methyl‐4‐benzoyl‐5‐pyrazolone 4‐ethyl‐thiosemicarbazone (HL) and its copper(II), vanadium(V) and nickel(II) complexes: [Cu(L)(Cl)]·C<sub>2</sub>H<sub>5</sub>OH·(<bold>1</bold>), [Cu(L)<sub>2</sub>]·H<sub>2</sub>O (<bold>2</bold>), [Cu(L)(Br)]·H<sub>2</sub>O·CH<sub>3</sub>OH (<bold>3</bold>), [Cu(L)(NO<sub>3</sub>)]·2C<sub>2</sub>H<sub>5</sub>OH (<bold>4</bold>), [VO<sub>2</sub>(L)]·2H<sub>2</sub>O (<bold>5</bold>), [Ni(L)<sub>2</sub>]·H<sub>2</sub>O (<bold>6</bold>), were synthesized and characterized. The ligand has been characterized by elemental analyses, IR, <sup>1</sup>H NMR and <sup>13</sup>C NMR spectroscopy. The tridentate nature of the ligand is evident from the IR spectra. The copper(II), vanadium(V) and nickel(II) complexes have been characterized by different physico‐chemical techniques such as molar conductivity, magnetic susceptibility measurements and electronic, infrared and electron paramagnetic resonance spectral studies. The structures of the ligand and its copper(II) (<bold>2</bold>, <bold> 4</bold>), and vanadium(V) (<bold>5</bold>) complexes have been determined by single‐crystal X‐ray diffraction. The composition of the coordination polyhedron of the central atom in <bold>2</bold>, <bold> 4</bold> and <bold>5</bold> is different. <italic>The tetrahedral coordination</italic> geometry of Cu was found in complex <bold>2</bold> while in complex <bold>4</bold>, it is square planar, in complex <bold>5</bold> the coordination polyhedron of the central ion is distorted square pyramid. The <italic>in vitro</italic> antibacterial activity of the complexes against <italic>Escherichia coli</italic>, <italic> Salmonella abony</italic>, <italic> Staphylococcus aureus</italic>, <italic> Bacillus cereus</italic> and the antifungal activity against <italic>Candida albicans</italic> strains was higher for the metal complexes than for free ligand. The effect of the free ligand and its metal complexes on the proliferation of HL‐60 cells was tested.</p> </abstract>