Clotting Activity of Polyphosphate‐Functionalized Silica Nanoparticles1. Issue 13 (4th February 2015)

• Record Type: Journal Article
• Authors: Kudela, Damien; Smith, Stephanie A.; May‐Masnou, Anna; Braun, Gary B.; Pallaoro, Alessia; Nguyen, Chi K.; Chuong, Tracy T.; Nownes, Sara; Allen, Riley; Parker, Nicholas R.; Rashidi, Hooman H.; Morrissey, James H.; Stucky, Galen D.
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 13(2015)
• Page Start: 4018
• Page End: 4022
• Publication Date: 2015-02-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201409639
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood‐clotting system; short‐chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood‐clotting system, both by accelerating fibrin generation and by facilitating the regulatory anticoagulation mechanisms essential for hemostasis. Analysis of the clotting properties of bare SNPs, bare polyP, and polyP‐functionalized SNPs in plasma demonstrated that the attachment of polyP to SNPs to form polyP‐SNPs creates a substantially enhanced synergistic effect that lowers clotting time and increases thrombin production at low concentrations. PolyP‐SNP even retains its clotting function at ambient temperature. The polyP‐SNP system has the potential to significantly improve trauma‐treatment protocols and outcomes in hospital and prehospital settings.</p> </abstract>