Applying the Retro‐Enantio Approach To Obtain a Peptide Capable of Overcoming the Blood–Brain Barrier1. Issue 13 (4th February 2015)

• Record Type: Journal Article
• Authors: Prades, Roger; Oller‐Salvia, Benjamí; Schwarzmaier, Susanne M.; Selva, Javier; Moros, María; Balbi, Matilde; Grazú, Valeria; de La Fuente, Jesus M.; Egea, Gustavo; Plesnila, Nikolaus; Teixidó, Meritxell; Giralt, Ernest
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 13(2015)
• Page Start: 3967
• Page End: 3972
• Publication Date: 2015-02-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201411408
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The blood–brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly controls the passage of molecules from the blood to the brain. In fact, less than 2 % of all potential neurotherapeutics are able to cross it. Here, by applying the retro‐enantio approach to a peptide that targets the transferrin receptor, a full protease‐resistant peptide with the capacity to act as a BBB shuttle was obtained and thus enabled the transport of a variety of cargos into the central nervous system.</p> </abstract>