Ultrathin Iron Oxide Nanowhiskers as Positive Contrast Agents for Magnetic Resonance Imaging. (1st December 2014)

• Record Type: Journal Article
• Authors: Macher, Thomas; Totenhagen, John; Sherwood, Jennifer; Qin, Ying; Gurler, Demet; Bolding, Mark S.; Bao, Yuping
• Is Part Of: Advanced functional materials. Volume 25:Number 3(2014)
• Page Start: 490
• Page End: 494
• Publication Date: 2014-12-01
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201403436
• Languages: English
• ISSNs: 1616-301X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In this paper, a highly innovative concept of using ultrathin iron oxide nanowhiskers as a positive (T₁) contrast agent for magnetic resonance imaging (MRI) is demonstrated. Iron oxide nanowhiskers with dimensions of approximately 2 nm × 20 nm are synthesized by heating an iron oleate/oleylamine complex under 150 °C. These nanostructures have very high surface‐to‐volume ratios, leading to strong paramagnetic signal, a property suitable for T₁ contrast in MRI. The positive contrast enhancement of these nanowhiskers is demonstrated in vitro and in vivo in a rat model. Successful development of this technology has substantial commercial value in biomedical imaging, potentially leading to the advancement of human healthcare technologies.</p> </abstract>