Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study. (January 2015)

• Record Type: Journal Article
• Authors: Leduc, Bernard E.; Fournier, Christine; Jacquemin, Géraldine; Lepage, Yves; Vinet, Bernard; Hétu, Pierre-Olivier; Chagnon, Miguel
• Is Part Of: Journal of spinal cord medicine. Volume 38:Number 1(2015:Jan.)
• Page Start: 57
• Page End: 62
• Publication Date: 2015-01
• Subjects: Spinal cord -- Wounds and injuries -- Periodicals; Spinal cord -- Diseases -- Periodicals; 616.8305
• DOI: 10.1179/2045772314Y.0000000225
• Languages: English
• ISSNs: 1079-0268

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <sec> <title>Objective</title> <p>The objective of this study is to evaluate the efficacy of midodrine in the treatment of anejaculation in men with spinal cord injury (SCI).</p> </sec> <sec> <title>Study design</title> <p>Prospective, double-blind, randomized, placebo-controlled pilot study.</p> </sec> <sec> <title>Method</title> <p>Men with anejaculation associated with SCI (level of injury above T10) of more than 1 year in duration were approached. Those with no ejaculatory response to one penile vibratory stimulation (PVS) trial were assigned in a double-blind manner to one of the two following interventions once a week for a maximum of 3 weeks or until ejaculation occurred: oral administration of flexible midodrine (7.5–22.5 mg max) followed by PVS (group M), or oral administration of flexible sham-midodrine (placebo) followed by PVS (group P). Sociodemographic data, medical characteristics, and plasma desglymidodrine concentration were collected for all participants.</p> </sec> <sec> <title>Outcome measure</title> <p>Ejaculation success rate in each group.</p> </sec> <sec> <title>Results</title> <p>Among the 78 men approached, 23 participants (level of SCI: C4–T9) were randomized. Three participants abandoned the study and 20 completed the study; 10 were assigned to group M, 10 to group P. Ejaculation was reached for one participant of group M and for two participants of group P. Autonomic dysreflexia associated to PVS occurred in three patients.</p> </sec> <sec> <title>Conclusion</title> <p>In this small sample study, treatment of anejaculation after SCI with midodrine and PVS did not result in a better rate of antegrade ejaculation in 10 men than in 10 men treated with a placebo and PVS.</p> </sec> </abstract>