Antioxidant, anti-inflammatory potential and chemical constituents of Origanum dubium Boiss., growing wild in Cyprus. (February 2015)

• Record Type: Journal Article
• Authors: Karioti, Anastasia; Milošević-Ifantis, Tanja; Pachopos, Nikitas; Niryiannaki, Niki; Hadjipavlou-Litina, Dimitra; Skaltsa, Helen
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 30:Number 1(2015:Feb.)
• Page Start: 38
• Page End: 43
• Publication Date: 2015-02
• Subjects: Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.3109/14756366.2013.871008
• Languages: English
• ISSNs: 1475-6366

Abstract

<abstract> <title>Abstract</title> <p> <italic>Origanum dubium</italic> Boiss. is a flavouring herb widely used in Cyprus. In this study, both lipophilic and polar extracts of the aerial parts of <italic>O. dubium</italic> were investigated for their chemical contents and their antioxidant potential. Overall, 20 constituents were isolated and identified, belonging mainly to three significant classes of compounds: terpenes, phenolic derivatives, such as hydroquinone glycosides and flavonoids and alicyclic derivatives. None of them was previously reported as constituent of <italic>O. dubium</italic> The inhibitory potencies of all total extracts and the isolated compounds on lipid peroxidation and their interaction with 1, 1-diphenyl-picrylhydrazyl (DPPH) activity is discussed. The polar extract showed strong interaction with DPPH stable radical and significant inhibition of lipoxygenase and lipid peroxidation.</p> </abstract>