Nesfatin-1 correlates with hypertension in overweight or obese Han Chinese population. (February 2015)

• Record Type: Journal Article
• Authors: Zhao, Yanyan; Ma, Xiaojun; Wang, Qingzhu; Zhou, Yingni; Zhang, Yuanyuan; Wu, Lina; Ji, Hongfei; Qin, Guijun; Lu, Jieli; Bi, Yufang; Ning, Guang
• Is Part Of: Clinical and experimental hypertension. Volume 37:Number 1(2015)
• Page Start: 51
• Page End: 56
• Publication Date: 2015-02
• Subjects: Hypertension -- Chemotherapy -- Periodicals; Hypotensive agents -- Periodicals; 616.132
• DOI: 10.3109/10641963.2014.897722
• Languages: English
• ISSNs: 1064-1963

Abstract

<abstract> <title>Abstract</title> <p>We investigated blood nesfatin-1 levels in hypertension patients. We found that fasting plasma nesfatin-1 levels were significantly higher in hypertension patients than in control groups, especially in overweight/obese hypertension patients (4.5 ± 2.1 versus 3.3 ± 1.1 ng/ml, <italic>p</italic> &lt; 0.01). Body mass index, systolic blood pressure and diastolic blood pressure were indeed positively correlated with fasting plasma nesfatin-1 levels (<italic>r</italic> = 0.234, <italic>p</italic> &lt; 0.05; <italic>r</italic> = 0.304, <italic>p</italic> &lt; 0.01; <italic>r</italic> = 0.251, <italic>p</italic> &lt; 0.05; <italic>r</italic> = 0.461, <italic>p</italic> &lt; 0.01; respectively). Logistic regression analysis revealed that the plasma level of nesfatin-1 could be independent of risk prediction over standard measures (OR = 1.547, 95% CI: 1.153–6.273, <italic>p</italic> = 0.026). Nesfatin-1 has the incremental contribution to hypertension risk prediction (IDI: 0.014, <italic>p</italic> = 0.018; NRI: 0.050, <italic>p</italic> = 0.043). The plasma nesfatin-1 level in hypertension patients with microalbuminuria are significantly higher than those without microalbuminuria patients (6.4 ± 2.1 ng/ml versus 3.9 ± 1.8 ng/ml, <italic>p</italic> &lt; 0.01). Nesfatin-1 might play an important role in obesity hypertension, and its increase could be a risk factor for obesity-associated hypertension.</p> </abstract>