Development of Two‐Channel Phosphorescent Core–Shell Nanoprobe for Ratiometric and Time‐Resolved Luminescence Imaging of Intracellular Oxygen Levels. (4th August 2014)

• Record Type: Journal Article
• Authors: Sun, Huibin; Zhang, Jie; Zhang, Kenneth Yin; Liu, Shujuan; Liang, Hua; Lv, Wen; Qiao, Weili; Liu, Xiangmei; Yang, Tianshe; Zhao, Qiang; Huang, Wei
• Is Part Of: Particle and particle systems characterization. Volume 32:Number 1(2015:Jan.)
• Page Start: 48
• Page End: 53
• Publication Date: 2014-08-04
• Subjects: Particles -- Periodicals; 620.43
• DOI: 10.1002/ppsc.201400106
• Languages: English
• ISSNs: 0934-0866

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="ppsc201400106-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>An effective strategy is developed to realize a ratiometric oxygen nanoprobe with two‐channel phosphorescence signals based on a core–shell silica nanoparticle.</bold> This nanoprobe exhibits good water dispersibility and biocompatibility. Bioimaging experiments demonstrate that the nanoprobe can be used for monitoring the change in intracellular O₂ concentration and performing quantitative O₂ measurement through ratiometric and time‐resolved luminescence bioimaging. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh31wfks78" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>