Design of Smart Oligo(ethylene glycol)‐Based Biocompatible Hybrid Microgels Loaded with Magnetic Nanoparticles. Issue 1 (25th November 2014)

• Record Type: Journal Article
• Authors: Boularas, Mohamed; Gombart, Emilie; Tranchant, Jean‐François; Billon, Laurent; Save, Maud
• Is Part Of: Macromolecular rapid communications. Volume 36:Issue 1(2015:Jan.)
• Page Start: 79
• Page End: 83
• Publication Date: 2014-11-25
• Subjects: Macromolecules -- Periodicals; Polymers -- Periodicals; Chemistry -- Periodicals; 547.705
• DOI: 10.1002/marc.201400578
• Languages: English
• ISSNs: 1022-1336

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This article reports a rational strategy for preparing smart oligo(ethylene glycol)‐based hybrid microgels loaded with high content of homogeneously distributed preformed magnetic nanoparticles (NPs) (up to 33 wt%). The strategy is based on the synthesis of biocompatible multiresponsive microgels by precipitation copolymerization of di(ethylene glycol) methyl ether methacrylate, oligo(ethylene glycol) methyl ether methacrylate, methacrylic acid, and oligo(ethylene glycol)diac­rylate. An aqueous dispersion of preformed magnetic NPs is straightforwardly loaded into the microgels. Robust monodisperse thermoresponsive magnetic microgels are produced, exhibiting a constant value of the volume phase transition temperature whatever the NPs content. The homogeneous microstructure of the initial stimuli‐responsive biocompatible microgels plays a crucial role for the design of unique well‐defined ethylene glycol‐based thermoresponsive hybrid microgels. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh30w8sptc" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>