Amperometric In Vitro Monitoring of Penetration through Skin Membrane. Issue 1 (6th November 2014)

• Record Type: Journal Article
• Authors: Gari, Hala; Rembiesa, Jadwiga; Masilionis, Ignas; Vreva, Naida; Svensson, Birgitta; Sund, Torbjörn; Hansson, Henri; Morén, Anna Karin; Sjöö, Malin; Wahlgren, Marie; Engblom, Johan; Ruzgas, Tautgirdas; Gorton, Lo
• Is Part Of: Electroanalysis. Volume 27:Issue 1(2015:Jan.)
• Page Start: 111
• Page End: 117
• Publication Date: 2014-11-06
• Subjects: Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201400426
• Languages: English
• ISSNs: 1040-0397

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real‐time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.</p> </abstract>