Left ventricular mechanical function: clinical correlates, heritability, and association with parental heart failure. (1st December 2014)

• Record Type: Journal Article
• Authors: Cheng, Susan; McCabe, Elizabeth L.; Larson, Martin G.; Chen, Ming‐Huei; Osypiuk, Ewa; Lehman, Birgitta T.; Stantchev, Plamen; Aragam, Jayashri; Solomon, Scott D.; Benjamin, Emelia J.; Vasan, Ramachandran S.
• Is Part Of: European journal of heart failure. Volume 17:Number 1(2015)
• Page Start: 44
• Page End: 50
• Publication Date: 2014-12-01
• Subjects: Heart failure -- Periodicals; Heart Failure -- Periodicals; Insuffisance cardiaque -- Périodiques; Heart failure; Periodicals; 616.129005
• DOI: 10.1002/ejhf.202
• Languages: English
• ISSNs: 1388-9842

Abstract

<abstract abstract-type="main" id="ejhf202-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ejhf202-sec-0001" sec-type="section"> <title>Aims</title> <p id="ejhf202-para-0001">Non‐invasive measures of cardiac mechanical function may have the potential to serve as markers of risk for heart failure; however, limited data exist regarding clinical correlates and heritability of these measures in the community.</p> </sec> <sec id="ejhf202-sec-0002" sec-type="section"> <title>Methods and results</title> <p id="ejhf202-para-0002">We used speckle‐tracking echocardiography to assess LV strain and synchrony in the Framingham Offspring Study (<italic>n</italic> = 2816; mean age 67 years, 54% women). In multivariable regression analyses, male gender (vs. female, <italic>P</italic> < 0.001), higher heart rate (<italic>P</italic> < 0.0001), and presence of cardiovascular disease (<italic>P</italic> < 0.001) were associated with worse global peak strains across all planes analysed (longitudinal, transverse, circumferential, and radial). Higher diastolic blood pressure and diabetes were associated with worse longitudinal strain (<italic>P</italic> < 0.01), and greater body mass index was associated with worse radial strain (<italic>P</italic> = 0.0004). Overall, however, clinical correlates accounted for only 4–19% of the variation in measures of LV mechanical function. Select measures of LV strain were heritable: longitudinal strain (<italic>h</italic><sup>2</sup> = 16%, <italic>P</italic> = 0.002), transverse strain (<italic>h</italic><sup>2</sup> = 15%, <italic>P</italic> = 0.006), and circumferential strain (<italic>h</italic><sup>2</sup> = 30%, <italic>P</italic> < 0.0001). Furthermore, in a subset of 1437 participants with parental data available, parental heart failure was associated with worse circumferential strain in the offspring free of heart failure (<italic>P</italic> = 0.01).</p> </sec> <sec id="ejhf202-sec-0003" sec-type="section"> <title>Conclusions</title> <p id="ejhf202-para-0003">Our investigation in a large community‐based sample identified heritablity and clinical correlates of LV mechanical function, and highlighted an association of parental heart failure with worse global circumferential strain in offspring.</p> </sec> </abstract>