Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension. (4th November 2014)

• Record Type: Journal Article
• Authors: Querejeta Roca, Gabriela; Campbell, Patricia; Claggett, Brian; Vazir, Ali; Quinn, Debbie; Solomon, Scott D.; Shah, Amil M.
• Is Part Of: European journal of heart failure. Volume 17:Number 1(2015)
• Page Start: 63
• Page End: 73
• Publication Date: 2014-11-04
• Subjects: Heart failure -- Periodicals; Heart Failure -- Periodicals; Insuffisance cardiaque -- Périodiques; Heart failure; Periodicals; 616.129005
• DOI: 10.1002/ejhf.177
• Languages: English
• ISSNs: 1388-9842

Abstract

<abstract abstract-type="main" id="ejhf177-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ejhf177-sec-0001" sec-type="section"> <title>Aims</title> <p id="ejhf177-para-0001">As pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH.</p> </sec> <sec id="ejhf177-sec-0002" sec-type="section"> <title>Methods and results</title> <p id="ejhf177-para-0002">Right ventricular free wall longitudinal strain (FWLS) and LV global circumferential strain (CS) were measured at baseline, 12 weeks, and 24 weeks in 68 patients with advanced PAH randomized to imatinib or placebo in the Imatinib in Pulmonary arterial hypertension, a Randomized Efficacy Study (IMPRES) trial, and compared with 30 healthy controls. Compared with controls, PAH was associated with impaired RV FWLS (–15.9 ± 5.4 vs. –30.8 ± 4.3, respectively; <italic>P</italic> < 0.0001) and LV septal CS (–24.2 ± 8.2 vs. –31.4 ± 5.3, respectively, <italic>P</italic> < 0.0001), but not LV global CS. Improvement in PVR and mean pulmonary artery pressure (MPAP) over a 24‐week period was significantly associated with improvement in RV FWLS (<italic>r</italic> = 0.39, <italic>P</italic> = 0.02; 0.33, <italic>P</italic> = 0.04 respectively), LV global CS (<italic>r</italic> = 0.61, <italic>P</italic> = 0.0001; <italic>r</italic> = 0.60, <italic>P</italic> = 0.0001, respectively), and LV septal CS (<italic>r</italic> = 0.50, <italic>P</italic> = 0.005; <italic>r</italic> = 0.56, <italic>P</italic> = 0.002, respectively). These associations were most robust with LV global and septal CS. Imatinib therapy was associated with improvement in RV FWLS compared with placebo.</p> </sec> <sec id="ejhf177-sec-0003" sec-type="section"> <title>Conclusions</title> <p id="ejhf177-para-0003">PAH is associated with impaired biventricular deformation. Reduction in PVR is associated with improvements in both RV and LV deformation, coupled to improvements in MPAP and stroke volume index, with LV global and septal CS the strongest correlates of these changes. RV FWLS is sensitive to treatment effect, demonstrating greater improvement with imatinib compared with placebo.</p> <p id="ejhf177-para-0004"> <bold>Trial registration:</bold> NCT00902174</p> </sec> </abstract>