Bio‐Based Nitriles from the Heterogeneously Catalyzed Oxidative Decarboxylation of Amino Acids. Issue 2 (3rd December 2014)

• Record Type: Journal Article
• Authors: Claes, Laurens; Matthessen, Roman; Rombouts, Ine; Stassen, Ivo; De Baerdemaeker, Trees; Depla, Diederik; Delcour, Jan A.; Lagrain, Bert; De Vos, Dirk E.
• Is Part Of: ChemSusChem. Volume 8:Issue 2(2015:Jan.)
• Page Start: 345
• Page End: 352
• Publication Date: 2014-12-03
• Subjects: Green chemistry -- Periodicals; Sustainable engineering -- Periodicals; Chemistry -- Periodicals; Chemical engineering -- Periodicals; 660
• DOI: 10.1002/cssc.201402801
• Languages: English
• ISSNs: 1864-5631

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The oxidative decarboxylation of amino acids to nitriles was achieved in aqueous solution by in situ halide oxidation using catalytic amounts of tungstate exchanged on a [Ni, Al] layered double hydroxide (LDH), NH₄Br, and H₂O₂ as the terminal oxidant. Both halide oxidation and oxidative decarboxylation were facilitated by proximity effects between the reactants and the LDH catalyst. A wide range of amino acids was converted with high yields, often &gt;90 %. The nitrile selectivity was excellent, and the system is compatible with amide, alcohol, and in particular carboxylic acid, amine, and guanidine functional groups after appropriate neutralization. This heterogeneous catalytic system was applied successfully to convert a protein‐rich byproduct from the starch industry into useful bio‐based N‐containing chemicals.</p> </abstract>